A trial comparing placebo, 5% and 10% minoxidil solution on the scalps of men experiencing male pattern plešavost surprisingly found that the efficacy of minoxidil was not dose-dependant as 5% minoxidil was significantly more effective at regrowing hair than 10% minoxidil1.
Topical minoxidil is currently the only approved Zdravljenje for androgenetic alopecia (male pattern plešavost), ki ne spremeni ravni hormonov v serumu, saj je edino drugo odobreno zdravljenje peroralni finasterid, ki zmanjša endogeno proizvodnjo močnega moškega hormona dihidrotestosterona2. Zato je to zdravljenje zelo zanimivo za veliko skupnost moških, ki se borijo proti androgenetski alopeciji (AGA).
Ta študija je vključevala skupno 90 moških z AGA, razvrščenih v 3 skupine: 0 % (placebo), 5 % in 10 % zdravljenje z raztopino minoksidila1 (za referenco, 5% minoksidil je najpogostejša komercialno dostopna formula minoksidila). Zdravljenje je trajalo 36 tednov, skupina s placebom pa skoraj ni doživela sprememb v številu vertex (krona) in čelnih dlak.1. Kot je bilo pričakovano, sta skupini s 5 % in 10 % minoksidila ponovno zrasli1. Presenetljivo pa je bilo, da je bil 5% minoksidil 9-krat učinkovitejši pri ponovni rasti las na vrhu vrha kot 10% minoksidil.1. Poleg tega je bil 5% minoksidil nekoliko bolj učinkovit kot 10% pri ponovni rasti čelnih las1. Nazadnje, koža irritation and hair shedding (this is observed in scalp hair prior to regrowth during minoxidil treatment) was more prominent in the 10% minoxidil group than the 5% minoxidil group1.
Te ugotovitve so zelo presenetljive glede na to, da običajno obstaja razmerje med odmerkom in odzivom z naraščajočim odmerkom drog corresponding to an increase in the desired outcome of the drug as well as increase in side effects, not a decrease in desired outcome as observed in this study. These results indicate that there may be an optimal concentration of minoxidil solution which provides maximal hair regrowth for the scalp and increasing beyond this threshold reduces regrowth. This suggests that the higher concentrations of minoxidil like 10% and higher that can be found easily online and are often experimented with in the communities experiencing izpadanje las, should be avoided as they have worse safety profiles and also less benefits.
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Reference:
- Ghonemy S Alarawi A., in Bessar, H. 2021. Učinkovitost in varnost novega 10 % topičnega minoksidila v primerjavi s 5 % topikalnega minoksidila in placeba pri zdravljenju moške androgenetske alopecije: trihoskopska ocena. Časopis za dermatološko zdravljenje. Letnik 32, 2021 – številka 2. DOI: https://doi.org/10.1080/09546634.2019.1654070
- Ho CH, Sood T, Zito PM. Androgena alopecija. [Posodobljeno 2021. maja 5]. V: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; januar 2021. Na voljo od: https://www.ncbi.nlm.nih.gov/books/NBK430924/
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